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The Best Place To Find The Cheapest Nexium
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Drug name:
Nexium
What is
Nexium?
Nexium decreases the amount
of acid produced in the stomach. The medication is used to
treat ulcers, gastroesophageal reflux disease
(GERD or heartburn), erosive esophagitis, and
other conditions involving excessive stomach acid
production. Nexium may also be used for purposes
other than those listed in this medication
guide.
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How does the medicine work?
Each acid-producing cell contains millions
of acid pumps. NEXIUM works by decreasing the acid
produced by these acid pumps. As you can see in this
drawing, NEXIUM turns off (deactivates) some of the
pumps to keep acid production under control. By reducing
acid production in the stomach, NEXIUM reduces the
chance of acid backing up into the esophagus and causing
reflux symptoms.
How to take the medicine:
Your healthcare professional will tell you
how and when to take NEXIUM. NEXIUM is available as a
capsule, which comes in different dosage strengths. Your
healthcare professional will prescribe the dose that is
right for you.
Taking NEXIUM should be part of your usual
routine so that you do not forget to take it. NEXIUM
capsules should be taken before meals and swallowed
whole (the capsules should never be chewed or crushed).
If you have a hard time swallowing capsules, you can
empty a capsule into a tablespoon of applesauce. The
applesauce should be eaten right away and never stored
for later use. The pellets should not be chewed or
crushed.
Do not use NEXIUM to treat any other
medical conditions unless instructed by your healthcare
professional. Never share NEXIUM with anyone else - it
has been prescribed for you!
Nexium is a proton pump inhibitor (PPI)
used to treat heartburn, or gastroesophageal reflux. It
may be used in combination with two antibiotics to treat
Helicobacter pylori (H. pylori) infection and duodenal
ulcers. Nexium may also be used to treat other
conditions as determined by your doctor. General
Information about Nexuim
Nexium has been approved by the FDA for
the relief of heartburn and other symptoms associated
with gastroesophageal reflux disease (GERD) and for the
healing of erosive esophagitis, a potentially serious
condition associated with GERD. The FDA also approved
Nexium for maintenance of healing of erosive esophagitis
and, in combination with amoxicillin and clarithromycin,
for the eradication of Helicobacter pylori
infection in patients with duodenal ulcer disease.
Nexium is derived from Prilosec
(omeprazole). Prilosec contains a racemic mixture of the
D- and L- forms (isomers) of omeprazole. Nexium contains
only one of the isomers. Both Prilosec and Nexium are
known as proton pump inhibitors.
As many as 25 million adults experience
heartburn on a daily basis. Although heartburn is the
most common symptom of GERD, the condition is also often
marked by other symptoms - such as a sour taste in the
mouth or difficulty swallowing - related to the backing
up of harsh stomach acid into the esophagus. When this
acid reflux damages the lining of the esophagus, it may
lead to a potentially more serious condition called
erosive esophagitis that can lead to narrowing or
ulceration of the esophagus.
Clinical results:
Four multicenter, double-blind, randomized
trials evaluated the healing rates of Nexium 40 mg,
Nexium 20 mg, and omeprazole 20 mg in subjects with
endoscopically diagnosed erosive esophagitis. Healing
rates were evaluated at week four and eight. At week
eight, healing rates were higher with Nexium treatment
compared to omeprazole in all four studies.
Two multicenter, randomized, double-blind,
placebo-controlled 4-arm trials evaluated the long-term
maintenance of healing of erosive esophagitis in
patients taking Nexium. The trials included subjects
with endoscopically confirmed, healed erosive
esophagitis, and they evaluated Nexium 40 mg, 20 mg and
10 mg once-daily over six months of treatment. Subjects
remained in remission significantly longer and the
number of recurrences of erosive esophagitis was
significantly less in subjects treated with Nexium
compared to placebo.
Nexium's effectiveness in the resolution
of GERD symptoms was evaluated in two
multicenter, randomized, double-blind,
placebo-controlled trials. These trials were conducted
in a total of 717 subjects, and they compared four weeks
of treatment with Nexium 20 mg or 40 mg once daily
versus placebo. The percentage of subjects who were
symptom-free of heartburn was significantly higher in
the Nexium groups compared to placebo at all follow-up
visits (weeks 1, 2 and 4).
In three European symptomatic GERD trials,
no significant treatment related differences were
observed between Nexium 20 mg and 40 mg and omeprazole
20 mg.
Nexium in combination with amoxicillan and
clarithromycin was tested in two multicenter,
randomized, double-blind trials for the eradication of
Helicobacter pylori (H. pylori) in subjects with
duodenal ulcer disease. H. pylori eradication rates at
four weeks post-therapy were significantly higher in the
Nexium plus amoxicillin and clarithromycin group than in
a Nexium plus clarithromycin or Nexium alone group.
Possible side effects:
Nexium can cause side effects. Some of
these side effects are minor and usually do not require
you to stop taking the medicine. Others may be more
serious.
The most common side effects
are:
• Headache
• Diarrhea
• Abdominal Pains
Other serious stomach conditions may still
exist. For a complete listing of all the side effects
that have been reported with the use of medication, ask your
healthcare professional to talk to you about the full
important product information.
Storage instructions:
Keep Nexium out of the reach of children
and always replace the bottle cap after use. Leave
Nexium in the original package and protect the medicine
from sunlight and moisture. Store the medication at room
temperature (between 59°F and 86°F or between 15°C and
30°C).
Side effects:
Side effects
include (but are not limited
to) the following:
•
Headache
• Diarrhea
• Abdominal pain
Safety and effectiveness have not yet been
established in pediatric patients.
Please consult your physician for further
information on side effects or to discuss the individual
appropriateness of Nexium treatment.
Mechanism of action:
Esomeprazole is a
proton pump inhibitor that suppresses gastric acid
secretion by specific inhibition of H+/K+-ATPase in the
gastric parietal cell. By acting specifically on the
proton pump, esomeprazole blocks the final step in acid
production, thus reducing gastric acidity. This effect is dose-related
up to a daily dose of 20 to 40 mg and leads
to inhibition of gastric acid secretion.
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Propecia